Bufo is a powerful and potent psychedelic that comes from the Colorado River (or Sonoran Desert) Toad. Bufo alvarius medicine made its way mainstream(ish) out of secrecy in 2011. Using Bufo helps you put ego aside to enable connecting with a divine source. The substance derived from that venom (and also found in some psychoactive plants) is 5-MeO-DMT, an extremely potent psychedelic that is four to six times stronger than its better-known relative DMT (or dimethyltryptamine).
Some say smoking the substance is a life-altering experience, causing intense and relatively short-lived effects—start to finish, about 30 minutes—that are powerfully transformative (in a good way). In a recent study published by the National Institutes of Health, after just a single-use, this psychedelic lifted anxiety, depression, and post-traumatic stress disorder (PTSD)—and provided an overall sustained enhancement of satisfaction with life. Interestingly enough, though some 5-MeO-DMT plants have a history of traditional use (like ayahuasca), there is no evidence or lineage of any indigenous Bufo alvarius practices.